Article
Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway.
Skeletal muscle - 1 Jan 2016
Shin Junchul, Nunomiya Aki, Kitajima Yasuo, Dan Takashi, Miyata Toshio, Nagatomi Ryoichi
Abstract excerpt
BACKGROUND: Hypoxia exposure is known to induce an alteration in skeletal muscle fiber-type distribution mediated by hypoxia-inducible factor (HIF)-α. The downstream pathway of HIF-α leading to fiber-type shift, however, has not been elucidated. The calcineurin pathway is one of the pathways responsible for slow muscle fiber transition. Because calcineurin pathway is activated by vascular endothelial growth...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.