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Article

Hypoxia and podocyte-specificVhlhdeletion confer risk of glomerular disease

4 Jul 2007

Abstract excerpt

Hypoxia is a potent regulator of a multitude of cellular processes, including metabolism and cell survival. The transcriptional response to oxygen deprivation is mainly mediated by hypoxia-inducible factors (HIFs), which are targeted for proteasomal degradation by the von Hippel-Lindau tumor suppressor protein (pVHL) under normoxia. Podocytes, as part of the glomerular filtration barrier, are prone to hypoxic...

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PMID: 17609290
DOI: 10.1152/ajprenal.00133.2007

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