Article
Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.
Kidney international - 1 Dec 2017
Kobayashi Hanako, Liu Jiao, Urrutia Andres A, Burmakin Mikhail, Ishii Ken, Rajan Malini, Davidoff Olena, Saifudeen Zubaida, Haase Volker H
Abstract excerpt
Hypoxia in the embryo is a frequent cause of intra-uterine growth retardation, low birth weight, and multiple organ defects. In the kidney, this can lead to low nephron endowment, predisposing to chronic kidney disease and arterial hypertension. A key component in cellular adaptation to hypoxia is the hypoxia-inducible factor pathway, which is regulated by prolyl-4-hydroxylase domain (PHD) dioxygenases PHD1,...
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