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Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis

6 Mar 2017

Abstract excerpt

Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High VSG expression within an expression site body (ESB) is mediated by RNA polymerase I (Pol I), which in other eukaryotes exclusively transcribes ribosomal RNA genes (rDNA). As T. brucei is reliant on Pol I for VSG transcription, we investigated Pol I transcription inhibitors for...

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PMID: 28263991
DOI: 10.1371/journal.pntd.0005432

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