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Article

RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essential.

Molecular and biochemical parasitology - 1 Aug 2004

Bakshi Rahul P, Shapiro Theresa A

Abstract excerpt

Type IB topoisomerases are enzymes essential for the orderly synthesis of nucleic acids and are the molecular target for antitumor camptothecins. In dozens of organisms, including eukaryotes, bacteria, and viruses, this enzyme is monomeric. However, we previously found that topoisomerase IB in trypanosomes is a heteromultimer, comprised of two distinct subunits encoded by separate genes. A large 90 kDa subunit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15478803
DOI: 10.1016/j.molbiopara.2004.04.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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