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Article

Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes

3 Jun 2005

Abstract excerpt

Trypanosoma brucei is a protozoan parasite that causes African sleeping sickness. T. brucei multiplies extracellularly in the bloodstream, relying on antigenic variation of a dense variant surface glycoprotein (VSG) coat to escape antibody-mediated lysis. We investigated the role of VSG in proliferation and pathogenicity by using inducible RNA interference to ablate VSG transcript down to 1-2% normal levels....

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PMID: 15937117
DOI: 10.1073/pnas.0501886102

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