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Article

Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease.

The Journal of clinical investigation - 3 Apr 2017

Tanaka Motomasa, Ishizuka Koko, Nekooki-Machida Yoko, Endo Ryo, Takashima Noriko, Sasaki Hideyuki, Komi Yusuke, Gathercole Amy, Huston Elaine, Ishii Kazuhiro, Hui Kelvin Kai-Wan, Kurosawa Masaru, Kim Sun-Hong, Nukina Nobuyuki, Takimoto Eiki, Houslay Miles D, Sawa Akira

Abstract excerpt

Huntington's disease (HD) is a polyglutamine (polyQ) disease caused by aberrant expansion of the polyQ tract in Huntingtin (HTT). While motor impairment mediated by polyQ-expanded HTT has been intensively studied, molecular mechanisms for nonmotor symptoms in HD, such as psychiatric manifestations, remain elusive. Here we have demonstrated that HTT forms a ternary protein complex with the scaffolding protein...

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Share to Cyclic Nucleotide Phosphodiesterases, Type 4
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntingtin Protein

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Source

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Identifiers

PMID: 28263187
DOI: 10.1172/JCI85594
PMCID: PMC5373889

Genes

DISC1
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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