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Article

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.

The Journal of biological chemistry - 17 Oct 2003

Busch Anne, Engemann Sabine, Lurz Rudi, Okazawa Hitoshi, Lehrach Hans, Wanker Erich E

Abstract excerpt

Aggregation of huntingtin (htt) in neuronal inclusions is associated with the development of Huntington's disease (HD). Previously, we have shown that mutant htt fragments with polyglutamine (polyQ) tracts in the pathological range (>37 glutamines) form SDS-resistant aggregates with a fibrillar morphology, whereas wild-type htt fragments with normal polyQ domains do not aggregate. In this study we have...

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Identifiers

PMID: 12888569
DOI: 10.1074/jbc.M303354200

Genes

SDS
PQBP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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