Article

Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures

2024-09-11

Abstract excerpt

Huntington’s disease (HD) is a debilitating neurodegenerative disorder affecting an individual’s cognitive and motor abilities. HD is caused by mutation in the huntingtin gene producing a toxic polyglutamine-expanded protein (mHTT) and leading to degeneration in the striatum and cortex. Yet, the molecular signatures that underlie tissue-specific vulnerabilities remain unclear. Here, we investigate this aspect by l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d2dfe4b0-9c65-56cc-ac3f-7cc0e199d0d1
DOI: 10.1101/2024.09.07.611843

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signaturesDOI 10.1101/2024.09.07.611843Read

Structure-function dissection of huntingtin exon 1 identifies a PRD-driven modifier of neuronal toxicity in Huntington’s diseaseSemantic proximity Read

Genome-scale transcriptional regulatory network models for the mouse and human striatum predict roles for SMAD3 and other transcription factors in Huntington’s diseaseSemantic proximity Read

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1Semantic proximity Read

Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s DiseaseSemantic proximity Read

Progressive Remodeling of Global Protein Interaction Networks in a Mouse Model of TauopathySemantic proximity Read

Recent Advances in the Study of Huntingtin Interacting ProteinsSemantic proximity Read

Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.Semantic proximity Read

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease.Semantic proximity Read

Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington’s Disease Mouse ModelsSemantic proximity Read

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo.Semantic proximity Read

Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulationSemantic proximity Read

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington diseaseSemantic proximity Read