Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database.

BMC neurology - 28 Jun 2012

Kalathur Ravi Kiran Reddy, Hernández-Prieto Miguel A, Futschik Matthias E

Abstract excerpt

BACKGROUND: Huntington's disease (HD) is a fatal progressive neurodegenerative disorder caused by the expansion of the polyglutamine repeat region in the huntingtin gene. Although the disease is triggered by the mutation of a single gene, intensive research has linked numerous other genes to its pathogenesis. To obtain a systematic overview of these genes, which may serve as therapeutic targets, CHDI Foundation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Databases, Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Genetic Predisposition to Disease

Share to Huntington Disease

Share to Internationality

Share to Polymorphism, Single Nucleotide

Share to Proteome

Source

Open in PubMed Open full text

Identifiers

PMID: 22741533
DOI: 10.1186/1471-2377-12-47
PMCID: PMC3492045

Genes

CDK5
GRM1
HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database.PMID 22741533Read ↗

A meta-analysis of transcriptomic profiles from Huntington’s disease patients points to a pathophysiological role of CDC42, NFY, DLX1 and PRMT3Semantic proximity Read ↗

Identification of key genes and signaling pathway in the pathogenesis of Huntington's disease via bioinformatics and next generation sequencing data analysisSemantic proximity Read ↗

Huntington’s Disease: From Genetics to TherapeuticsSemantic proximity Read ↗

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease.Semantic proximity Read ↗

Huntington’s Disease Pathogenesis: Two Sequential ComponentsSemantic proximity Read ↗

Identification of Novel Biomarkers in Huntington’s Disease Based on differential Gene Expression Meta-Analysis and Machine Learning ApproachSemantic proximity Read ↗

The unfolded protein response and its potential role in Huntington's disease elucidated by a systems biology approachSemantic proximity Read ↗

Mutant-Huntingtin Molecular Pathways Elucidate New Targets for Drug Repurposing.Semantic proximity Read ↗

Huntington Disease: Genetics, Prevention, and Therapy Approaches.Semantic proximity Read ↗

From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington’s Disease ResearchSemantic proximity Read ↗

Identification of differentially expressed genes and regulatory relationships in Huntington's disease by bioinformatics analysis.Semantic proximity Read ↗

Huntington's disease: underlying molecular mechanisms and emerging concepts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.