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Article

Ionic tethering contributes to the conformational stability and function of complement C3b.

Molecular immunology - 1 May 2017

López-Perrote Andrés, Harrison Reed E S, Subías Marta, Alcorlo Martín, Rodríguez de Córdoba Santiago, Morikis Dimitrios, Llorca Oscar

Abstract excerpt

C3b, the central component of the alternative pathway (AP) of the complement system, coexists as a mixture of conformations in solution. These conformational changes can affect interactions with other proteins and complement regulators. Here we combine a computational model for electrostatic interactions within C3b with molecular imaging to study the conformation of C3b. The computational analysis shows that the...

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Identifiers

PMID: 28254726
DOI: 10.1016/j.molimm.2016.12.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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