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Article

Complement Gene Variants Define the Conformational Dynamics of C3 Convertase.

European journal of immunology - 1 Jul 2026

Martín Merinero Héctor, Welsh Seth J, Xu Zhen, Smith Richard J H, Zhang Yuzhou

Abstract excerpt

Current understanding of the structure, function, and molecular dynamics of the alternative pathway C3-convertase has been shaped by the clinical impact of genetic variants in complement genes. Characterizing the functional impact of different mutations not only provides patient-specific insights into the pathogenic mechanisms underlying a number of complement-mediated diseases but, at a broader level, allows us...

Topics

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Complement C3
Complement System Proteins
C3 gene
CFB gene
CFI gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 42484458
DOI: 10.1002/eji.70242
PMCID: PMC13390585

Genes

C3
CFB
CFD
CFH
CFI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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