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Article

A revised mechanism for the activation of complement C3 to C3b: a molecular explanation of a disease-associated polymorphism.

The Journal of biological chemistry - 23 Jan 2015

Rodriguez Elizabeth, Nan Ruodan, Li Keying, Gor Jayesh, Perkins Stephen J

Abstract excerpt

The solution structure of complement C3b is crucial for the understanding of complement activation and regulation. C3b is generated by the removal of C3a from C3. Hydrolysis of the C3 thioester produces C3u, an analog of C3b. C3b cleavage results in C3c and C3d (thioester-containing domain; TED)....

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Identifiers

PMID: 25488663
DOI: 10.1074/jbc.M114.605691
PMCID: PMC4303685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25488663-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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