Article
New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: analysis of the epidermal growth factor-like repeat A docking site using WaterMap.
Proteins - 1 Sept 2010
Pearlstein Robert A, Hu Qi-Ying, Zhou Jing, Yowe David, Levell Julian, Dale Bethany, Kaushik Virendar K, Daniels Doug, Hanrahan Susan, Sherman Woody, Abel Robert
Abstract excerpt
LDL cholesterol (LDL-C) is cleared from plasma via cellular uptake and internalization processes that are largely mediated by the low-density lipoprotein cholesterol receptor (LDL-R). LDL-R is targeted for lysosomal degradation by association with proprotein convertase subtilisin-kexin type 9 (PCSK9). Gain of function mutations in PCSK9 can result in excessive loss of receptors and dyslipidemia. On the other...
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