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Article

Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells.

PLoS genetics - 1 Mar 2017

Kasela Silva, Kisand Kai, Tserel Liina, Kaleviste Epp, Remm Anu, Fischer Krista, Esko Tõnu, Westra Harm-Jan, Fairfax Benjamin P, Makino Seiko, Knight Julian C, Franke Lude, Metspalu Andres, Peterson Pärt, Milani Lili

Abstract excerpt

Inappropriate activation or inadequate regulation of CD4+ and CD8+ T cells may contribute to the initiation and progression of multiple autoimmune and inflammatory diseases. Studies on disease-associated genetic polymorphisms have highlighted the importance of biological context for many regulatory variants, which is particularly relevant in understanding the genetic regulation of the immune system and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28248954
DOI: 10.1371/journal.pgen.1006643
PMCID: PMC5352142

Genes

RPS26
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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