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Article

Mice with reduced NMDA receptor expression: more consistent with autism than schizophrenia?

Genes, brain, and behavior - 1 Aug 2012

Gandal M J, Anderson R L, Billingslea E N, Carlson G C, Roberts T P L, Siegel S J

Abstract excerpt

Reduced NMDA-receptor (NMDAR) function has been implicated in the pathophysiology of neuropsychiatric disease, most strongly in schizophrenia but also recently in autism spectrum disorders (ASD). To determine the direct contribution of NMDAR dysfunction to disease phenotypes, a mouse model with constitutively reduced expression of the obligatory NR1 subunit has been developed and extensively investigated. Adult...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22726567
DOI: 10.1111/j.1601-183X.2012.00816.x
PMCID: PMC3808979

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