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Article

Gabrb2-knockout mice displayed schizophrenia-like and comorbid phenotypes with interneuron-astrocyte-microglia dysregulation.

Translational psychiatry - 17 Jul 2018

Yeung Rigil K, Xiang Zheng-Hua, Tsang Shui-Ying, Li Rui, Ho Timothy Y C, Li Qi, Hui Chok-King, Sham Pak-Chung, Qiao Ming-Qi, Xue Hong

Abstract excerpt

Intronic polymorphisms of the GABAA receptor β2 subunit gene (GABRB2) under adaptive evolution were associated with schizophrenia and reduced expression, especially of the long isoform which differs in electrophysiological properties from the short isoform. The present study was directed to examining the gene dosage effects of Gabrb2 in knockout mice of both heterozygous (HT) and homozygous (KO) genotypes with...

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Identifiers

PMID: 30013074
DOI: 10.1038/s41398-018-0176-9
PMCID: PMC6048160

Genes

GABRB2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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