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Article

CYP1A2 rs762551 polymorphism and risk for amyotrophic lateral sclerosis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Jan 2021

Siokas Vasileios, Karampinis Emmanouil, Aloizou Athina-Maria, Mentis Alexios-Fotios A, Liakos Panagiotis, Papadimitriou Dimitra, Liampas Ioannis, Nasios Grigorios, Bogdanos Dimitrios P, Hadjigeorgiou Georgios M, Dardiotis Efthimios

Abstract excerpt

BACKGROUND: Genetic variability is considered to confer susceptibility to amyotrophic lateral sclerosis (ALS). Oxidative stress is a significant contributor to ALS-related neurodegeneration, and it is regulated by cytochromes P450 (CYPs), such as CYP1A2; these are responsible for the oxidative metabolism of both exogenous and endogenous substrates in the brain, subsequently impacting ALS. The function of CYP1A2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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PMID: 32592103
DOI: 10.1007/s10072-020-04535-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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