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Article

RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism.

Journal of cellular and molecular medicine - 1 Mar 2009

Kölsch Heike, Lütjohann Dieter, Jessen Frank, Popp Julius, Hentschel Frank, Kelemen Peter, Friedrichs Silvia, Maier T A Wolfgang, Heun Reinhard

Abstract excerpt

Cholesterol metabolism is altered in Alzheimer's disease (AD). The nuclear hormone receptor Retinoic X Receptor a (RXRa) is a member of the nuclear ligand-activated transcription factor family. RXRs are key regulators of cholesterol synthesis and thus cholesterol metabolism. We performed a systematic screen for gene variants in the RXRA gene. The effect of these gene variants on the risk of AD was investigated in...

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Identifiers

PMID: 19374686
DOI: 10.1111/j.1582-4934.2009.00383.x
PMCID: PMC3822518

Genes

RXRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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