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Article

The common, autoimmunity-predisposing 620Arg > Trp variant of PTPN22 modulates macrophage function and morphology.

Journal of autoimmunity - 1 May 2017

Li Meihang, Beauchemin Hugues, Popovic Natalija, Peterson Alan, d'Hennezel Eva, Piccirillo Ciriaco A, Sun Chao, Polychronakos Constantin

Abstract excerpt

The C1858T single nucleotide polymorphism (SNP) in PTPN22 (protein tyrosine phosphatase nonreceptor 22) leads to the 620 Arg to Trp polymorphism in its encoded human protein LYP. This allelic variant is associated with multiple autoimmune diseases, including type 1 diabetes (T1D), Crohn's disease, rheumatoid arthritis and systemic lupus erythematosus. However, the underlying mechanisms are poorly understood. To...

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Identifiers

PMID: 28237724
DOI: 10.1016/j.jaut.2017.01.009

Genes

PTPN22

Variants

Provenance

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