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Article

A novel spontaneous mutation in the TAP2 gene unravels its role in macrophage survival.

Immunology - 1 Apr 2017

Lapenna Antonio, Omar Ibrahim, Berger Michael

Abstract excerpt

We report a new mouse strain with a single point mutation in the type 2 transporter associated with antigen processing (TAP2). This strain randomly arose in one of our C57BL/6J mouse colonies and was initially discovered because of the lack of CD8+ T cells in the periphery. Following our observation, we subsequently revealed a lack of cell surface MHC-I expression, derived from TAP2 protein deficiency. Our...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 3
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Survival

Share to Histocompatibility Antigens Class I

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Source

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Identifiers

PMID: 27861817
DOI: 10.1111/imm.12694
PMCID: PMC5343342

Genes

TAP2

Provenance

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