Article
Design and investigation of interactions of novel peptide conjugates of purine and pyrimidine derivatives with EGFR and its mutant T790M/L858R: an in silico and laboratory study.
Molecular diversity - 1 Dec 2024
Hunt Hannah L, Goncalves Beatriz G, Biggs Mary A, Rico Mia I, Murray Molly E, Lebedenko Charlotta G, Banerjee Ipsita A
Abstract excerpt
Peptide-based therapeutics have been gaining attention due to their ability to actively target tumor cells. Additionally, several varieties of nucleotide derivatives have been developed to reduce cell proliferation and induce apoptosis of tumor cells. In this work, we have developed novel peptide conjugates with newly designed purine analogs and pyrimidine derivatives and explored the binding interactions with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.