Article

Computational revealing Infigratinib resistance to the FGFR2 N549H and N549K mutations

2024-12-17

Abstract excerpt

Fibroblast growth factor receptor 2 (FGFR2) is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. The clinically acquired FGFR2 N549H/K mutations make the treatment of Infigratinib ineffective. Here, molecular docking, multiple-replica molecular dynamics (MD) simulations, and binding free energy calculations were used to reveal...

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Literature Corpus work: 74e92bf9-6f22-586c-9594-89423706a7f8
DOI: 10.1080/17458080.2024.2442305

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