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Article

Association of COMT and TPH-2 genes with DSM-5 based PTSD symptoms.

Journal of affective disorders - 1 Feb 2015

Goenjian Armen K, Noble Ernest P, Steinberg Alan M, Walling David P, Stepanyan Sofia T, Dandekar Sugandha, Bailey Julia N

Abstract excerpt

BACKGROUND: Dopaminergic and serotonergic systems have been implicated in PTSD. The present study evaluated the association of four catechol-O-methyltransferase (COMT) gene loci, and the joint effect of COMT and tryptophan hydroxylase 2 (TPH2) genes on PTSD symptoms. METHODS: Subjects included 200 Caucasian Armenian adults exposed to the 1988 Spitak earthquake from 12 multigenerational (3-5 generations) families....

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Source

Identifiers

PMID: 25451452
DOI: 10.1016/j.jad.2014.10.034

Genes

COMT
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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