Article
Catechol-O-methyltransferase Val158Met polymorphism moderates anterior cingulate volume in posttraumatic stress disorder.
Biological psychiatry - 1 Dec 2011
Schulz-Heik R Jay, Schaer Marie, Eliez Stephan, Hallmayer Joachim F, Lin Xiaoyan, Kaloupek Danny G, Woodward Steven H
Abstract excerpt
BACKGROUND: Posttraumatic stress disorder (PTSD) is associated with structural and functional compromise of the anterior cingulate cortex (ACC), which may in turn be associated with impairment of its ability to regulate the amygdala. The Val158Met polymorphism in the catechol-O-methyltransferase gene, which substantially influences dopamine inactivation in the frontal lobe in general and in ACC in particular, may...
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