Article
Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type colorectal cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2012
Imamura Yu, Morikawa Teppei, Liao Xiaoyun, Lochhead Paul, Kuchiba Aya, Yamauchi Mai, Qian Zhi Rong, Nishihara Reiko, Meyerhardt Jeffrey A, Haigis Kevin M, Fuchs Charles S, Ogino Shuji
Abstract excerpt
PURPOSE: To assess prognostic roles of various KRAS oncogene mutations in colorectal cancer, BRAF mutation status must be controlled for because BRAF mutation is associated with poor prognosis, and almost all BRAF mutants are present among KRAS wild-type tumors. Taking into account experimental data supporting a greater oncogenic effect of codon 12 mutations compared with codon 13 mutations, we hypothesized that...
Topics
- Class I Phosphatidylinositol 3-Kinases
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- Humans
- Kaplan-Meier Estimate
- Long Interspersed Nucleotide Elements
- Microsatellite Instability
- Mutation