Article
Involvement of K-RAS mutations and amino acid substitutions in the survival of metastatic colorectal cancer patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2012
Pérez-Ruiz Elisabeth, Rueda A, Pereda T, Alcaide J, Bautista D, Rivas-Ruiz F, Villatoro R, Pérez D, Redondo M
Abstract excerpt
The efficacy of epidermal growth factor-targeting therapies has been found to be limited in tumors with the wild-type K-RAS gene, suggesting a predictive value of K-RAS gene analysis in tumoral response. However, the prognostic value of K-RAS is controversial. This study included patients diagnos...
Topics
- Adult
- Aged
- Aged, 80 and over
- Amino Acid Substitution
- Colorectal Neoplasms
- DNA, Neoplasm
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Neoplasm Staging
- Polymerase Chain Reaction
- Prognosis
- Proto-Oncogene Proteins