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Article

Involvement of K-RAS mutations and amino acid substitutions in the survival of metastatic colorectal cancer patients.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2012

Pérez-Ruiz Elisabeth, Rueda A, Pereda T, Alcaide J, Bautista D, Rivas-Ruiz F, Villatoro R, Pérez D, Redondo M

Abstract excerpt

The efficacy of epidermal growth factor-targeting therapies has been found to be limited in tumors with the wild-type K-RAS gene, suggesting a predictive value of K-RAS gene analysis in tumoral response. However, the prognostic value of K-RAS is controversial. This study included patients diagnosed with metastatic colorectal cancer. The presence of K-RAS mutations was analyzed, and the tumors positive for a K-RAS...

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PMID: 22791568
DOI: 10.1007/s13277-012-0442-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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