Article
Prevalence of KRAS G12C Mutation and Co-mutations and Associated Clinical Outcomes in Patients With Colorectal Cancer: A Systematic Literature Review.
The oncologist - 2 Nov 2023
Strickler John H, Yoshino Takayuki, Stevinson Kendall, Eichinger Christian Stefan, Giannopoulou Christina, Rehn Marko, Modest Dominik Paul
Abstract excerpt
PURPOSE: A systematic literature review was conducted to estimate the global prevalence of Kirsten rat sarcoma virus gene (KRAS) mutations, with an emphasis on the clinically significant KRAS G12C mutation, and to estimate the prognostic significance of these mutations in patients with colorectal cancer (CRC). DESIGN: Relevant English-language publications in the Embase, MEDLINE, and the Cochrane Library...
Topics
- Humans
- Proto-Oncogene Proteins p21(ras)
- Prevalence
- Colorectal Neoplasms
- Neoplasm Recurrence, Local
- Mutation
- Lung Neoplasms