Article
[Induction of robust senescence-associated secretory phenotype in mouse NIH-3T3 cells by mitomycin C].
Sheng li xue bao : [Acta physiologica Sinica] - 25 Feb 2017
Huang Wei-Xing, Guo Xiao-Xuan, Peng Zhong-Zhi, Weng Chun-Liang, Huang Chun-Yan, Shi Ben-Yan, Yang Jie, Liao Xiao-Xin, Li Xiao-Yi, Zheng Hui-Ling, Liu Xin-Guang, Sun Xue-Rong
Abstract excerpt
Senescence-associated secretory phenotype (SASP) is often a concomitant result of cell senescence, embodied by the enhanced function of secretion. The SASP factors secreted by senescent cells include cytokines, proteases and chemokines, etc, which can exert great influence on local as well as systemic environment and participate in the process of cell senescence, immunoregulation, angiogenesis, cell proliferation...
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