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Article

Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells.

Antioxidants & redox signaling - 20 Mar 2016

Jin Hye Jin, Lee Hyang Ju, Heo Jinbeom, Lim Jisun, Kim Miyeon, Kim Min Kyung, Nam Hae Yun, Hong Gyong Hwa, Cho You Sook, Choi Soo Jin, Kim In-Gyu, Shin Dong-Myung, Kim Seong Who

Abstract excerpt

AIMS: Cellular senescence and its secretory phenotype (senescence-associated secretory phenotype [SASP]) develop after long-term expansion of mesenchymal stromal cells (MSCs). Further investigation of this phenotype is required to improve the therapeutic efficacy of MSC-based cell therapies. In this study, we show that positive feedback between SASP and inherent senescence processes plays a crucial role in the...

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Source

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Identifiers

PMID: 26573462
DOI: 10.1089/ars.2015.6359
PMCID: PMC4800271

Genes

BMI1
MSC
CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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