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Article

The impact of cellular senescence and senescence‑associated secretory phenotype in cancer‑associated fibroblasts on the malignancy of pancreatic cancer.

Oncology reports - 1 May 2023

Higashiguchi Masaya, Murakami Hirotomo, Akita Hirofumi, Kobayashi Shogo, Takahama Shokichi, Iwagami Yoshifumi, Yamada Daisaku, Tomimaru Yoshito, Noda Takehiro, Gotoh Kunihito, Doki Yuichiro, Yamamoto Takuya, Eguchi Hidetoshi

Abstract excerpt

Cancer‑associated fibroblasts (CAFs) are implicated in the strong malignancy of pancreatic cancer (PC). Various CAF subtypes have different functions, and their heterogeneity likely influence the malignancy of PC. Meanwhile, it is known that senescent cells can create a tumor‑promoting microenvironment by inducing a senescence‑associated secretory phenotype (SASP). In the present study, the effects of individual...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36999632
DOI: 10.3892/or.2023.8535
PMCID: PMC10091076

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