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Article

Senescence‐associated secretory phenotype promotes chronic ocular graft‐vs‐host disease in mice and humans

3 Jul 2020

Abstract excerpt

Chronic graft-vs-host disease (cGVHD) is a multifactorial inflammatory disease that affects patients undergoing hematopoietic stem cell transplantation. Multiple organs, including the lacrimal glands (LGs), are negatively affected by cGVHD and lose function due to the resultant fibrosis. An abnormal immune response is thought to be a major factor in the development of chronic ocular GVHD, which is currently...

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PMID: 32619061
DOI: 10.1096/fj.201900218r

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