Article
The RET p.G533C mutation confers predisposition to multiple endocrine neoplasia type 2A in a Brazilian kindred and is able to induce a malignant phenotype in vitro and in vivo.
Thyroid : official journal of the American Thyroid Association - 1 Sept 2011
Oliveira Mariana N L, Hemerly Jefferson P, Bastos André U, Tamanaha Rosana, Latini Flavia R M, Camacho Cléber P, Impellizzeri Anelise, Maciel Rui M B, Cerutti Janete M
Abstract excerpt
BACKGROUND: We have previously described a p.G533C substitution in the rearranged during transfection (RET) oncogene in a large family with medullary thyroid carcinoma. Here, we explore the functional transforming potential of RET p.G533C mutation. METHODS: Plasmids expressing RET mutants (p.G533C and p.C634Y) and RET wild type were stable transfected into a rat thyroid cell line (PCCL3). Biological and...
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