Article

A Testable Model of Temporal Genomic Memory in Cancer Initiation Driven by Metabolic-Epigenetic Coupling

2026-05-11

Abstract excerpt

Cancer initiation is commonly interpreted through mutation-centered models in which tumor development results from the progressive accumulation of genetic alterations. Although this framework remains essential, it does not fully account for the long latency of many cancers, the persistence of cellular phenotypes after removal of environmental stressors, or the stable epigenetic changes associated with chronic meta...

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Literature Corpus work: 73ea39a3-f2a3-50b1-a2b4-599d2c8d555a
DOI: 10.20944/preprints202605.0614.v1

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