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Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell Immortalization

10 Jun 2009

Abstract excerpt

The timing and progression of DNA methylation changes during carcinogenesis are not completely understood. To develop a timeline of aberrant DNA methylation events during malignant transformation, we analyzed genome-wide DNA methylation patterns in an isogenic human mammary epithelial cell (HMEC) culture model of transformation. To acquire immortality and malignancy, the cultured finite lifespan HMEC must...

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Share to Epigenetics and DNA Methylation
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Share to Telomeres, Telomerase, and Senescence

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PMID: 19509227
DOI: 10.1158/0008-5472.can-08-4977

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