A Non-Genetic Basis for Cancer Progression and Metastasis: Self-Organizing Attractors in Cell Regulatory Networks

Abstract excerpt

It is commonly assumed that somatic evolution drives the multi-step process that produces metastatic cancer. But it is difficult to reconcile the inexorable progression towards metastasis in virtually all carcinomas and the associated complex change of cancer cell phenotype, characterized by an epithelial-to-mesenchymal transition, with the random nature of gene mutations. Given their irreversible nature, it is...

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