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Article

Senescence-Inflammatory Regulation of Reparative Cellular Reprogramming in Aging and Cancer

5 May 2017

Abstract excerpt

The inability of adult tissues to transitorily generate cells with functional stem cell-like properties is a major obstacle to tissue self-repair. Nuclear reprogramming-like phenomena that induce a transient acquisition of epigenetic plasticity and phenotype malleability may constitute a reparative route through which human tissues respond to injury, stress, and disease. However, tissue rejuvenation should...

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PMID: 28529938
DOI: 10.3389/fcell.2017.00049

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