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Article

Phylodynamic Inference across Epidemic Scales.

Molecular biology and evolution - 1 May 2017

Volz Erik M, Romero-Severson Ethan, Leitner Thomas

Abstract excerpt

Within-host genetic diversity and large transmission bottlenecks confound phylodynamic inference of epidemiological dynamics. Conventional phylodynamic approaches assume that nodes in a time-scaled pathogen phylogeny correspond closely to the time of transmission between hosts that are ancestral to the sample. However, when hosts harbor diverse pathogen populations, node times can substantially pre-date infection...

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PMID: 28204593
DOI: 10.1093/molbev/msx077
PMCID: PMC5400386

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