Article

Integrating Transmission Dynamics and Pathogen Evolution Through a Bayesian Approach

2024-04-17

Abstract excerpt

The collection of pathogen samples and subsequent genetic sequencing enables the reconstruction of phylogenies, shedding light on transmission dynamics. However, many existing phylogenetic methods fall short by neglecting within-host diversity and the impact of transmission bottlenecks, leading to inaccuracies in understanding epidemic spread. This paper introduces the Transmission Tree (TnT) model, which leverag...

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Literature Corpus work: 1893b3f9-632f-52d4-aaa2-2bcb11415619
DOI: 10.1101/2024.04.15.589468

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