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Article

A Precise Genome Editing Method Reveals Insights into the Activity of Eukaryotic Promoters.

Cell reports - 3 Jan 2017

Elison Gregory L, Song Ruijie, Acar Murat

Abstract excerpt

Despite the availability of whole-genome sequences for almost all model organisms, making faithful predictions of gene expression levels based solely on the corresponding promoter sequences remains a challenge. Plasmid-based approaches and methods involving selection markers are not ideal due to copy-number fluctuations and their disruptive nature. Here, we present a genome editing method using the CRISPR/Cas9...

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Identifiers

PMID: 28052256
DOI: 10.1016/j.celrep.2016.12.014
PMCID: PMC5216458

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