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Genetic and Functional Study of L-Type Amino Acid Transporter 1 in Schizophrenia.

Neuropsychobiology - 1 Jan 2016

Comasco Erika, Vumma Ravi, Toffoletto Simone, Johansson Jessica, Flyckt Lena, Lewander Tommy, Oreland Lars, Bjerkenstedt Lars, Andreou Dimitrios, Söderman Erik, Terenius Lars, Agartz Ingrid, Jönsson Erik G, Venizelos Nikolaos

Abstract excerpt

Schizophrenia involves neural catecholaminergic dysregulation. Tyrosine is the precursor of catecholamines, and its major transporter, according to studies on fibroblasts, in the brain is the L-type amino acid transporter 1 (LAT1). The present study assessed haplotype tag single-nucleotide polymorphisms (SNPs) of the SLC7A5/LAT1 gene in 315 patients with psychosis within the schizophrenia spectrum and 233 healthy...

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PMID: 28190014
DOI: 10.1159/000455234

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