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Article

Evidence for a relationship between genetic polymorphisms of the L-DOPA transporter LAT2/4F2hc and risk of hypertension in the context of chronic kidney disease.

BMC medical genomics - 18 Jun 2024

Crocco Paolina, Dato Serena, La Grotta Rossella, Passarino Giuseppe, Rose Giuseppina

Abstract excerpt

BACKGROUND: Chronic kidney disease (CKD) and hypertension are chronic diseases affecting a large portion of the population frequently coexistent and interdependent. The inability to produce/use adequate renal dopamine may contribute to the development of hypertension and renal dysfunction. The heterodimeric amino acid transporter LAT2/4F2hc (SLC7A8/SLC3A2 genes) promotes the uptake of L-DOPA, the natural...

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Identifiers

PMID: 38890684
DOI: 10.1186/s12920-024-01935-2
PMCID: PMC11186288

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