Article
Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study.
Biological psychiatry - 15 Aug 2007
Praschak-Rieder Nicole, Kennedy James, Wilson Alan A, Hussey Douglas, Boovariwala Anahita, Willeit Matthaeus, Ginovart Nathalie, Tharmalingam Subi, Masellis Mario, Houle Sylvain, Meyer Jeffrey H
Abstract excerpt
BACKGROUND: The serotonin transporter (5-HTT)-linked polymorphic region (5-HTTLPR) has two frequent alleles, designated long (L), and short (S). The S allele is associated with lower levels of 5-HTT mRNA and lower 5-HTT expression in human cell lines. A functional single nucleotide variant was detected within L, designated L(A) and L(G). Only L(A) is associated with high levels of in vitro 5-HTT expression,...
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