Article
Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis.
Behavioral and brain functions : BBF - 29 Jul 2014
Andreou Dimitrios, Söderman Erik, Axelsson Tomas, Sedvall Göran C, Terenius Lars, Agartz Ingrid, Jönsson Erik G
Abstract excerpt
BACKGROUND: Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are the major monoamine metabolites in the central nervous system (CNS). Their cerebrospinal fluid (CSF) concentrations, reflecting the monoamine turnover rates in CNS, are partially under genetic influence and have been associated with schizophrenia. We have hypothesized that CSF monoamine...
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