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Article

WNK kinases influence TRPV4 channel function and localization.

American journal of physiology. Renal physiology - 1 Jun 2006

Fu Yi, Subramanya Arohan, Rozansky David, Cohen David M

Abstract excerpt

TRPV4, a renally expressed nonselective cation channel of the transient receptor potential (TRP) family, is gated by hypotonicity. Kinases of the WNK family influence expression and function of the thiazide-sensitive Na+-Cl- cotransporter, and monogenic human hypertension has been linked to mutations in the gene coding for WNK4. Along with TRPV4, WNK isoforms are highly expressed in the distal nephron. We show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16403833
DOI: 10.1152/ajprenal.00391.2005

Genes

TRPV4
WNK4
WNK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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