Article
The role of transient receptor potential channels in kidney disease.
Nature reviews. Nephrology - 1 Aug 2009
Woudenberg-Vrenken Titia E, Bindels René J M, Hoenderop Joost G J
Abstract excerpt
The transient receptor potential (TRP) superfamily consists, in mammals, of six protein subfamilies, TRPC, TRPM, TRPV, TRPA, TRPML and TRPP. TRPs are cation channels involved in many physiological processes and in the pathogenesis of various disorders. In the kidney, TRP channels are expressed along the nephron, and a role for some of these channels in renal function has been proposed. TRPC3 is thought to...
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