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Article

Mapping the methylation status of the miR-145 promoter in saphenous vein smooth muscle cells from individuals with type 2 diabetes.

Diabetes & vascular disease research - 1 Mar 2017

Riches Kirsten, Huntriss John, Keeble Claire, Wood Ian C, O'Regan David J, Turner Neil A, Porter Karen E

Abstract excerpt

Type 2 diabetes mellitus prevalence is growing globally, and the leading cause of mortality in these patients is cardiovascular disease. Epigenetic mechanisms such as microRNAs (miRs) and DNA methylation may contribute to complications of type 2 diabetes mellitus. We discovered an aberrant type 2 diabetes mellitus-smooth muscle cell phenotype driven by persistent up-regulation of miR-145. This study aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

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Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Source

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Identifiers

PMID: 28185533
DOI: 10.1177/1479164116677968
PMCID: PMC5305035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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