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Article

Induction of angiotensin-converting enzyme after miR-143/145 deletion is critical for impaired smooth muscle contractility.

American journal of physiology. Cell physiology - 15 Dec 2014

Dahan Diana, Ekman Mari, Larsson-Callerfelt Anna-Karin, Turczyńska Karolina, Boettger Thomas, Braun Thomas, Swärd Karl, Albinsson Sebastian

Abstract excerpt

MicroRNAs have emerged as regulators of smooth muscle cell phenotype with a role in smooth muscle-related disease. Studies have shown that miR-143 and miR-145 are the most highly expressed microRNAs in smooth muscle cells, controlling differentiation and function. The effect of miR-143/145 knockout has been established in the vasculature but not in smooth muscle from other organs. Using knockout mice we found...

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PMID: 25273883
DOI: 10.1152/ajpcell.00250.2014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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