Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-145 improves metabolic inflammatory disease through multiple pathways

2 Apr 2019

Abstract excerpt

Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes, yet the mechanisms are not completely understood. Here, we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control. miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics. LPS repressed the transcription of miR-143/145 cluster and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Cancer-related molecular mechanisms research
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30941422
DOI: 10.1093/jmcb/mjz015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-145 improves metabolic inflammatory disease through multiple pathwaysPMID 30941422Read ↗

miR-145 plays a role in mitochondria dysfunction in alveolar epithelial cells in LPS-induced ARDSSemantic proximity Read ↗

MicroRNA-155 Promotes Atherosclerosis Inflammation via Targeting SOCS1Semantic proximity Read ↗

MicroRNA‑145‑5p attenuates high glucose‑induced apoptosis by targeting the Notch signaling pathway in podocytesSemantic proximity Read ↗

Opposing functions of miR-155-5p and Socs1 drive vascular inflammation in diabetes-accelerated atherosclerosis.Semantic proximity Read ↗

MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4.Semantic proximity Read ↗

MiR-143/145 deficiency attenuates the progression of atherosclerosis in Ldlr-/-mice.Semantic proximity Read ↗

Opposite effects of miR-155 in the initial and later stages of lipopolysaccharide (LPS)-induced inflammatory responseSemantic proximity Read ↗

miR-145 micelles mitigate atherosclerosis by modulating vascular smooth muscle cell phenotype.Semantic proximity Read ↗

Role of microRNA-145 in DNA damage signalling and senescence in vascular smooth muscle cells of Type 2 diabetic patientsSemantic proximity Read ↗

Role of MicroRNA-145 in DNA Damage Signalling and Senescence in Vascular Smooth Muscle Cells of Type 2 Diabetic Patients.Semantic proximity Read ↗

miR-155 is high-expressed in polycystic ovarian syndrome and promotes cell proliferation and migration through targeting PDCD4 in KGN cellsSemantic proximity Read ↗

Harnessing mIR-145 deficiency to modulate inflammation and prevent degeneration in a mouse model of multiple sclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.