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Article

rs41291957 controls miR-143 and miR-145 expression and impacts coronary artery disease risk.

EMBO molecular medicine - 7 Oct 2021

Hall Ignacio Fernando, Climent Montserrat, Viviani Anselmi Chiara, Papa Laura, Tragante Vinicius, Lambroia Luca, Farina Floriana Maria, Kleber Marcus E, März Winfried, Biguori Carlo, Condorelli Gianluigi, Elia Leonardo

Abstract excerpt

The role of single nucleotide polymorphisms (SNPs) in the etiopathogenesis of cardiovascular diseases is well known. The effect of SNPs on disease predisposition has been established not only for protein coding genes but also for genes encoding microRNAs (miRNAs). The miR-143/145 cluster is smooth muscle cell-specific and implicated in the pathogenesis of atherosclerosis. Whether SNPs within the genomic sequence...

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Share to Coronary Artery Disease
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myocytes, Smooth Muscle

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 34551209
DOI: 10.15252/emmm.202114060
PMCID: PMC8495461

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